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P1* Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204). Koji Ohnishi1,2, Yoshihiro Komohara1, Yukio Fujiwara1, Kenichi Takemura1, XiaoFeng Lei1,3, Naomi Sakashita1, and Motohiro Takeya1 1Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University; 2Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto; 3Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan P2 Apoptosis of macrophages by N-Arachidonyl Glycine is mediated by GPR18. P3 EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Masatoshi Hori1, Tsuyoshi Tajima1,2, Takahisa Murata1, Kosuke Aritake3, Yoshihiro Urade3, Toshiyuki Matsuoka4, Syu Narumiya4, and Hiroshi Ozaki1 1Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan, 2Laboratory of Veterinary Pharmacology, Nippon Veterinary and Life Science University, Tokyo, Japan, 3Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan, 4Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan P4 Overexpression of Wiskott-Aldrich syndrome protein (WASP) N-terminal domain inhibits inflammatory responses in LPS-activated macrophages. P5 Silica and alum induce type 2 immunity via inflammasome-independent mechanisms. Etsushi Kuroda1, Ken J Ishii2,3 and Yasuo Morimoto4 1Department of Immunology and Parasitology and 4Department of Occupational Pneumology, University of Occupational and Environmental Health, Japan, 2Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Japan, 3Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan P6 Mint3 enhances the activity of HIF-1 in macrophages by suppressing the activity of FIH-1. P7* Spermine involved methylation status on ITGAL promoter possibly regulates the expression of LFA-1. P8 Tim-3 mediates phagocytosis of apoptotic cells by inflammatory macrophage and CD8+ dendritic cell subsets. Kazuyoshi Takeda,1 Masafumi Nakayama,1,2 Hisaya Akiba,1 Yuko Kojima,3 Hideo Yagita,1 Koetsu Ogasawara,2 and Ko Okumura1 1Department of Immunology and 3Division of Biomedical Imaging Research, Biomedical Research Center, Juntendo University School of Medicine, 3Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University P9 M-CSF-dependent red pulp macrophages regulate CD4 T cell responses. P10 Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta expression through NF-kB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells. P11 Absence of IFN-g accelerates thrombus resolution through enhanced MMP-9 and VEGF expression. P12 CCR7-independent trafficking of skin antigens to regional lymph nodes by cells in the dermis. P13 A proteasome inhibitor bortezomib suppresses immunostimulatory activity of human plasmacytoid dendritic cells by targeting intracellular trafficking of nucleic acid-sensing Toll-like receptors and endoplasmic reticulum homeostasis. Makiko Hirai,1 Norimitsu Kadowaki,2 Toshio Kitawaki,2 Haruyuki Fujita,2Akifumi Takaori-Kondo,2 Ryutaro Fukui,3 Kensuke Miyake,3 Takahiro Maeda,4 Shimeru Kamihira,5 Yoshiki Miyachi,1 Takashi Uchiyama 2, 6 1Department of Dermatology and 2Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 3Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan4Department of Island and Community Medicine, and 5Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan6Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, JapanP14 Z39Ig is a novel cell surface marker of macrophages in murine large intestine. P15* High-mobility Group Box-1 Protein Promotes Granulomatous Nephritis in Adenine-induced nephropathy. Yoko Oyama1, Teruto Hashiguchi1, Noboru Taniguchi2, Salunya Tancharoen3, Tomonori Uchimura1, Kamal K. Biswas1, Ko-ichi Kawahara1, Takao Nitanda4, Yoshihisa Umekita5, Martin Lotz2 and Ikuro Maruyama1 1Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, 3Pharmacology Department, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. 4Division of Surgical Pathology, Kagoshima University Hospital, Kagoshima, Japan. 5Department of Tumor Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. P16 Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kB (RANK). P17 The defensive role of interferon-g produced by myeloid cells in invasive group A Streptococcus infection. P18 Targeting of folate receptor b-expressing macrophages in bleomycin induced pulmonary fibrosis. P19 What are effector cells in the liver transplant rejection ? P20* Translocation of ACAT1 from ER to Late Endosomal Associated Membranes in Cholesterol-rich Human Macrophage. XiaoFeng Lei1,2, Naomi Sakashita2, Yukio Fujiwara2, Catherine CY Chang3, Ta-Yuan Chang3, Motohiro Takey2, Akira Miyazaki1 1 Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan, 2 Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, 3 Department of Biochemistry, Dartmouth Medical School, Hanover, NH, USA P21* Macrophage and neutrophils have different response to hypoxia in expression of long pentraxin 3 (PTX3) in human atherosclerosis. Alexander S. Savchenko1, Riuko Ohashi1, Kenji Inoue2, Shuying Jiang1,3, Go Hasegawa1, Makoto Naito1 1Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 2Department of Cardiology, Juntendo University Nerima Hospital, Tokyo, Japan, 3Perseus Proteomics Inc., Tokyo, Japan P22 A symbiotic growth of nasal NK/T-cell lymphoma cells with CD204-positive macrophages would defense themselves from endogenous reactive oxygen spices-induced cell necrosis. P23* Involvement of M2 macrophages in the ascites of advanced epithelial ovarian cancer in tumor progression via Stat3 activation. P24* Infiltration of macrophages plays a key role in tumor angiogenesis and progression. Kosuke Watari, Yuji Basaki, Michihiko Kuwano, Mayumi Ono Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan |
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